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Channel: Trial Methodology – Innovations in Clinical Neuroscience
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The Distinction between Clinical and Research Interviews in Psychiatry

by Steven D. Targum, MD Dr. Targum is a consultant for the Department of Psychiatry at the Massachusetts General Hospital. Dr. Targum is on the editorial board of Innovations in Clinical Neuroscience....

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The Use of Research Measures in Adult Clinical Practice

by Joan Busner, PhD; Stuart L. Kaplan, MD; Nicholas Greco, IV, MS; and David V. Sheehan, MD, MBA Dr. Busner is Clinical Associate Professor of Psychiatry, Penn State College of Medicine, and Practice...

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How Adaptive Trial Designs Can Increase Efficiency in Psychiatric Drug...

  by Joan Shen, MD; Sheldon Preskorn, MD; Vladimir Dragalin, PhD; Mary Slomkowski, PharmD; S. Krishna Padmanabhan, PhD; Parvin Fardipour, PhD; Amarnath Sharma, PhD; and Michael Krams, MD, PhD Dr. Shen...

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Use of a Relapse Monitoring Board: An Independent Assessment for Determining...

by Norris Turner, PharmD, PhD; Wayne Macfadden, MD; Ravi Anand, MD; Sumant Khanna, MD, PhD; Mark H. Rapaport, MD; J. Thomas Haskins, PhD; Ibrahim Turkoz, MS; and Larry Alphs, MD, PhD   Drs. Turner and...

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Development and Psychometric Evaluation of a Clinical Global Impression for...

  by Michael H. Allen, MD, DFAPA; David G. Daniel, MD; Dennis A. Revicki, PhD; Carla M. Canuso, MD; Ibrahim Turkoz, MS; Dong-Jing Fu, MD, PhD; Larry Alphs, MD, PhD; K. Jack Ishak, PhD; John J. Bartko,...

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It’s Only a Little Ice: A Personal View with Companion Commentary

  by Stephen G. Thein, PhD Dr. Thein is Director/Principal Investigator of Pacific Research Network, Inc., in San Diego, California. With companion commentary by Atul R. Mahableshwarkar, MD Dr....

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CNS Sites Cooperate to Detect Duplicate Subjects with a Clinical Trial...

by Thomas M. Shiovitz, MD; Charles S. Wilcox, PhD, MPA, MBA; Lilit Gevorgyan, BS; and Adnan Shawkat, BA Dr. Shiovitz is from CTSdatabase, LLC, in Beverly Hills, California and California Neuroscience...

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How Can Registries Contribute to the Development and Evaluation of CNS...

by Joanne B. Severe, MS, and Annette Stemhagen, DrPH, FISPE Ms. Severe is a research consultant in Rockville, Maryland, and Dr. Stemhagen is with United Biosource Corp. in Bethesda, Maryland. Innov...

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Study Site Experiences and Attitudes Toward Prospective Assessments of...

by Michelle Stewart, PhD; Adam Butler, PhD; Larry Alphs, MD, PhD; Phillip B. Chappell, MD; Douglas E. Feltner, MD; William R. Lenderking, PhD; Atul R. Mahableshwarkar, MD; Clare W. Makumi, PharmD, MBA;...

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Defining a Clinically Meaningful Effect for the Design and Interpretation of...

by Richard S. E. Keefe, PhD; Helena C. Kraemer, PhD; Robert S. Epstein, MD, MS; Ellen Frank, PhD; Ginger Haynes, PhD; Thomas P. Laughren, MD; James McNulty, AbScB; Shelby D. Reed, PhD; Juan Sanchez,...

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Do the Five Combinations of Suicidal Ideation in the FDA 2012 Draft Guidance...

by Jennifer M. Giddens and David V. Sheehan, MD, MBA J. Giddens is Co-founder of the Tampa Center for Research on Suicidality, Tampa, Florida; and Dr. Sheehan is Distinguished University Health...

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The Complexity of Assessing Overall Severity of Suicidality: A Case Study

by Jennifer M. Giddens and David V. Sheehan, MD, MBA J. Giddens is Co-founder of the Tampa Center for Research on Suicidality, Tampa, Florida; and Dr. Sheehan is Distinguished University Health...

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Linguistic Validation of the Pediatric Versions of the Sheehan Suicidality...

by Darlene M. Amado, BA; Darlene A. Beamon, BSE, MA; and David V. Sheehan, MD, MBA Mrs. Amado is with the University of South Florida College of Public Health and the University of South Florida...

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Status Update on the Sheehan-Suicidality Tracking Scale (S-STS) 2014

by David V. Sheehan, MD, MBA; Jennifer M. Giddens; and Ivan Sascha Sheehan, PhD Dr. D. Sheehan is Distinguished University Health Professor Emeritus at the University of South Florida College of...

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The Columbia–Suicide Severity Rating Scale (C–SSRS): Has the “Gold Standard”...

by Jennifer M. Giddens; Kathy Harnett Sheehan, PhD; and David V. Sheehan, MD, MBA J. Giddens is the Co-founder of the Tampa Center for Research on Suicidality, Tampa, Florida; Dr. K. Sheehan is...

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Current Assessment and Classification of Suicidal Phenomena using the FDA...

by David V. Sheehan, MD, MBA; Jennifer M. Giddens; and Kathy Harnett Sheehan, PhD Dr. D. Sheehan is Distinguished University Health Professor Emeritus at the University of South Florida College of...

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Simple Measures of Hopelessness and Impulsivity are Associated with Acute...

by Cheryl B. McCullumsmith, MD, PhD; David J. Williamson, PhD; Roberta S. May, MA; Emily H. Bruer, M.ed; David V. Sheehan, MD, MBA; and Larry D. Alphs, MD, PhD Dr. McCullumsmith is with the University...

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Comparative Validation of the S-STS, the ISST-Plus, and the C–SSRS for...

by David V. Sheehan, MD, MBA; Larry D. Alphs, MD, PhD; Lian Mao, PhD; Qin Li; Roberta S. May, MA; Emily H. Bruer, M.ed; Cheryl B. McCullumsmith, MD, PhD; Christopher R. Gray, BS; Xiaohua Li; and David...

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Predictive Value of Baseline Electronic Columbia–Suicide Severity Rating...

by John H. Greist, MD; James C. Mundt, PhD; Chad J. Gwaltney, PhD; James W. Jefferson, MD; and Kelly Posner, PhD Dr. Greist is Clinical Adjunct Professor of Psychiatry at University of Wisconsin School...

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Prospective Assessment of Suicidal Ideation and Behavior: An Internet Survey...

by ISCTM Suicidal Ideation and Behavior Assessment Workgroup: Phillip B. Chappell, MD; Atul R. Mahableshwarkar, MD; Larry D. Alphs, MD, PhD; Mark E. Bangs, MD; Adam Butler, BA; Sarah J. Dubrava, MS;...

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